E951 - Aspartame study denounced as flawed by The North American sweetener industry
Written by Chris Andrews on September 29th, 2005 in News, Sweeteners.
A study involving 1800 rats (equal quantities of male and female) had previously linked aspartame intake with increased lymphomas and leukemias in the female ones. The study was set up to stimulate the amount of aspartame that humans would take, but the industry argues that the amounts the scientists used was out - by a large factor. They hit out saying that “The researchers at Ramazzini have not followed the internationally established protocol for evaluation of animal carcinogenicity study findings,� said the organization. Their justification for this mainly being, it seems, that the Ramazzini study is not in the MedLine (National Library of Medicine) database.
Further Reading:
October 2nd, 2005 at 8:42 am
http://groups.yahoo.com/group/aspartameNM/message/1226
USA NIH National Toxicology Program aids eminent Ramazzini Foundation,
Bologna, Italy, in more results on cancers in rats from lifetime low
levels of aspartame (methanol, formaldehyde), Felicity Lawrence,
www.guardian.co.uk: Murray 2005.09.30
[ Comments by Rich Murray are in square brackets. ]
http://www.guardian.co.uk/food/Story/0,2763,1581639,00.html?gusrc=rss
Sweetener manufacturer disputes validity of new health research
* Study links aspartame with cancers
* Ingredient used in more than 6,000 products
Felicity Lawrence Friday September 30, 2005 The Guardian
Aspartame, the artificial sweetener used in more than 6,000 food and drink
products around the world, is the subject of renewed controversy this week
after the results of the latest research into whether it can cause cancer.
Scientists at the independent European Ramazzini Foundation for cancer
research in Bologna presented new results from its long-term, large-scale
study of the effect of aspartame on 1,800 rats, at its international
conference on cancer and environmental sciences in Italy last week.
[ www.ramazzini.it/living2005 ]
[ http://www.ramazzini.it/fondazione/docs/AspartameGEO2005.pdf ]
The research centre said analysis of its latest results showed aspartame
caused cancer of the kidney, and of the peripheral nerves, mainly in the
head.
Earlier data from the same study published in July linked aspartame to an
increased risk of leukaemias and lymphomas in female lab rats “at doses very
close to the acceptable daily intake for humans”.
Manufacturers of the sweetener have challenged the validity of the study.
They say the research is “in total conflict with hundreds of credible
studies that have been thoroughly reviewed by the regulatory authorities
around the world” and that “the allegations are inconsistent with human
epidemiological data”.
They question the record of the institute and say it is “criminal” for it to
present its data publicly before it had made it all available to the
regulatory authorities and before it had been fully reviewed.
Aspartame is roughly 200 times sweeter than sugar.
It is regularly consumed by more than 350 million people worldwide,
and is estimated to account for 62% of the market in sweetening agents.
It is commonly found in the UK in diet colas and other low-calorie drinks,
juices, sweets, chewing gum, cereals, yoghurts, other desserts, snack foods
such as crisps, medicines and vitamin supplements,
including those for children.
The European Food Safety Authority is not at present recommending any change
in consumers’ diets.
“Up to now aspartame has been considered safe, based on the studies
available,” it said.
It would review the research “as a matter of high priority, in the context
of previous extensive safety data available on aspartame”.
Aspartame has been authorised for use in foods for a long time but has a
“controversial history”, according to EFSA.
Because it is widely consumed, particularly by young children and pregnant
women, the European Ramazzini Foundation decided to carry out an unusually
large study of feeding aspartame to laboratory rats, according to its
director, Dr Morando Soffritti.
The rats were studied for nearly three years,
until the end of their natural lifespan;
most studies last about two years.
Six different dose levels were tested
against a control group not given aspartame.
The National Toxicology Programme of the US National Institutes of Health
convened a pathology working group to provide a second opinion on the
interpretation of some of the cancerous lesions
observed by the Ramazzini researchers,
and helped with the statistical evaluation of data.
The Italian scientists concluded that aspartame is a “multipotential
carcinogen”, causing a dose-related increase in leukaemias and lymphomas in
female rats,
and a dose-related increase in incidence of cancer and its precursors in the
kidney (renal pelvis and ureter)
as well as tumours in the peripheral nerves,
in particular in cranial nerves.
Aspartame is metabolised into aspartic acid, phenylalanine and methanol.
Methanol is in turn metabolised to formaldehyde.
Previous large-scale experiments by the Ramazzini Foundation have linked
both methanol and formaldehyde to a significant increase of leukaemias and
lymphomas, the researchers say.
However, they point out that the other sorts of cancer they observed in
their aspartame study did not show up in studies on methanol and
formaldehyde, suggesting an urgent need to study
whether aspartic acid or phenylalanine were also potential
carcinogens.
The researchers also found that while rats fed aspartame ate less food,
there was no difference in weight between treated and untreated animals.
The first results have been published in the foundation’s journal,
the European Journal of Oncology,
and have been peer-reviewed by seven international experts,
according to the journal’s editorial board.
The second results have not yet been peer-reviewed.
The foundation is now planning to enlarge its study to embryonic rats and
mice — work that will take several years to complete.
Meanwhile, one of the authors of the study, Fiorella Belpoggi said:
“In our opinion, the results of our first experiment on aspartame call for
urgent reconsideration of the rules governing its use as an artificial
sweetener.”
One of the largest manufacturers of aspartame, Ajinomoto,
the Japanese multinational which also makes monosodium glutamate,
has challenged the research.
Its senior scientists said they did not agree with the interpretation of
results,
nor did they believe that the study’s protocols met internationally approved
standards. [ These scientists should identify themselves and submit a
formal critical scientific report. ]
They said the results were not statistically significant,
that numerous studies had shown aspartame was safe,
and that regulatory bodies around the world had concluded it was safe.
“Aspartame has a record of 25 years of safe use.
Aspartame is made from amino acids and is broken down into common dietary
components.
Aspartame itself therefore brings nothing new to the diet,” a spokesman
said. “Raising ill-founded fears about an ingredient which helps people to
control calorie intake is not benign.”
The International Sweeteners Association said last week:
“Aspartame is one of the most tested food ingredients ever and all
evaluations undertaken by independent risk assessors at international,
European, and national level have concluded
that aspartame is a safe foodstuff …
Aspartame can make a useful contribution to weight control.
With billions of man-years of safe use,
there is no indication of an association
between aspartame and cancer in humans.”
Aspartame was approved for use by the US Food and Drug Administration in
1981, and for use in soft drinks a couple of years later.
The FDA looked at four previous studies conducted for the industry on
whether aspartame causes cancer.
One had reported an increase in brain tumours in rats, although the FDA
ruled that parts of the study were flawed.
Three others concluded it was not carcinogenic.
When the FDA reviewed all the data,
it concluded that there was no evidence of a carcinogenic effect on the
brains of animals.
A review of all the data on aspartame was carried out in 2002 by the
European commission’s scientific committee on food.
It concluded that it was safe and reconfirmed the previously established
acceptable daily intake of the additive.
Speaking on behalf of Ajinomoto, Ewan Currie, of the Aspartame Information
Service, said: “We are confident that when it has been scrutinised by third
parties, aspartame will be exonerated.”
[ http://www.aspartame.net/ http://www.aspartame.net/media/contact.asp
The Aspartame Information Service is provided by Ajinomoto Food Ingredients
LLC. Ajinomoto is a producer of aspartame. ]
Footnotes
Peripheral nerves: Parts of motor and sensory nerves, branch from the brain
and spinal cord
Leukaemias and lymphomas: Malignant diseases of the blood and lymphatic
system. Lymphomas are tumours arising from lymphoid tissue
Acceptable daily intake: The amount of an additive the regulatory
authorities calculate a person may eat/drink each day without causing any
known harm to health. The UK ADI for aspartame is 0-40 mg per kg of body
weight
[ 2800 mg for a 70 kg average person, the same as 14 12-oz diet sodas,
of which 11% [ in this example, 308 mg ] is methanol (wood alcohol), which
is quickly fully released into the body in the GI tract,
and soon largely converted into formaldehyde, and then formic acid,
both potent, cumulative toxins that harm every cell and tissue.
This much methanol is about the same as the methanol impurity in two liters
of red wine, which upon its inevitable conversion into formaldehyde, is
stated by many scientists to be the major cause of the infamous misery of
“next morning” hangover in the many especially susceptible users:
headache, weakness, nausea, body aches and pains, fatigue, irritability,
anxiety, confusion, brain fog, poor memory, dizziness, twitchy muscles, sore
eyes, poor vision, dry mouth, poor appetite, and, if repeated frequently for
years, progressive deterioration, severe liver and kidney problems,
ideopathic seizures, and addiction.
If only 30% of this much methanol is turned into formaldehyde,
that would be 93 mg formaldehyde,
which is 46.5 times the 2 mg daily limit for formaldehyde
in drinking water set by the USA EPA in 1999,
and 465 times the level set by the State of Maryland,
and 155 times the level set by California and Maine.
Prominent Americans like John Edwards, Joe Trippi, and Harvey Weinstein are
famous for drinking a dozen diet sodas a day for years. ]
Epidemiological data: The pattern of disease in the population as a whole
Special reports
Medicine and health
http://www.guardian.co.uk/medicine/0,11381,618095,00.html
Kelly’s war on junk food
http://www.guardian.co.uk/medicine/story/0,11381,1580634,00.html
September 29, leader: The biggest — and best — decision on health
yesterday was announced during the education session when Ruth Kelly, the
education secretary, announced foods high in fat, salt and sugar would be
banned both from school meals and in school vending machines by next
September.
http://groups.yahoo.com/group/aspartameNM/message/1224
UK bans high fat, salt, sugar foods in school meals and vending machines,
www.guardian.co.uk: Murray 2005.09.30
Useful links http://www.guardian.co.uk/medicine/0,11381,618095,00.html
British Medical Association http://www.bma.org.uk/ap.nsf/content/splashpage
Department of Health http://www.dh.gov.uk/Home/fs/en
General Medical Council http://www.gmc-uk.org/
Health on the Net Foundation http://www.hon.ch/
Institute of Cancer Research http://www.icr.ac.uk/
Medical Research Council http://www.mrc.ac.uk/
NHS Direct http://www.nhsdirect.nhs.uk/index.asp
Royal Institute of Public Health http://www.riph.org.uk/
World Health Organisation http://www.who.int/en/
***************************************************************
USA Department of Health and Human Services http://www.os.dhhs.gov/
USA National Institutes of Health http://www.nih.gov/
The National Institute of Environmental Health Sciences
http://www.niehs.nih.gov/
National Toxicology Program http://ntp.niehs.nih.gov/
http://www.ramazzini.it/eng/fondazione/pubblicazioni.asp
FONDAZIONE “B. RAMAZZINI” — Via Guerrazzi, 18 40125 Bologna, ITALIA 051
237286 fax 051 2911679 fondazione@ramazzini.it
CANCER RESEARCH CENTER — Castello di Bentivoglio, Via Saliceto, 3 40010
Bentivoglio Bologna, Italy
051.66.40.460 fax 051 6640223 crcfr@ramazzini.it
http://www.ramazzini.it/fondazione/docs/AspartameGEO2005.pdf
Original studies/Studi originali
General topics/Argomenti generali
Eur. J. Oncol., vol. 10, n. 2, pp. 00-00, 2005 IN PRESS
Aspartame induces lymphomas and leukaemias in rats *
L’aspartame induce linfomi e leucemie nei ratti
Morando Soffritti, [ 31 items in PubMed ]
Fiorella Belpoggi, [ 16 items in PubMed ]
Davide Degli Esposti, [ 0 items in PubMed ]
Luca Lambertini [ 15 items in PubMed ]
Cancer Research Centre, European Ramazzini Foundation of Oncology and
Environmental Sciences, Bologna, Italy
Received/Pervenuto 15.3.2005 - Accepted/Accettato 11.4.2005
Address/Indirizzo: Dr. Morando Soffritti, Centro di Ricerca sul Cancro,
Fondazione Europea di Oncologia e Scienze Ambientali “B. Ramazzini”,
Castello di Bentivoglio, 40010 Bentivoglio (BO), Italia - Tel.
+39/051/6640460 - Fax +39/051/6640223 - E-mail: crcfr@ramazzini.it
* Research supported by European Ramazzini Foundation of Oncology and
Environmental Sciences, Bologna, Italy
http://groups.yahoo.com/group/aspartameNM/message/1186
aspartame induces lymphomas and leukaemias in rats, full plain text,
M Soffritti, F Belpoggi, DD Esposti, L Lambertini: Ramazzini Foundation
study 2005.07.14: main results agree with their previous methanol and
formaldehyde studies: Murray 2005.09.27
http://groups.yahoo.com/group/aspartameNM/message/1189
Michael F Jacobson of CSPI now and in 1985 re aspartame toxicity, letter to
FDA Commissioner Lester Crawford; California OEHHA aspartame critique
2004.03.12; Center for Consumer Freedom denounces CSPI: Murray 2005.07.27
http://groups.yahoo.com/group/aspartameNM/message/1226
USA NIH National Toxicology Program aids eminent Ramazzini Foundation,
Bologna, Italy, in more results on cancers in rats from lifetime low
levels of aspartame (methanol, formaldehyde), Felicity Lawrence,
www.guardian.co.uk: Murray 2005.09.30
**************************************************************
Dark wines and liquors, as well as aspartame, provide similar levels of
methanol, above 100 mg daily, for long-term heavy users. Methanol is
inevitably largely turned into formaldehyde, and thence largely into formic
acid. It is the major cause of the dreaded symptoms of “next morning”
hangover.
Rich Murray, MA Room For All rmforall@comcast.net 505-501-2298
1943 Otowi Road Santa Fe, New Mexico 87505 USA
http://groups.yahoo.com/group/aspartameNM/messages
group with 149 members, 1,229 posts in a public, searchable archive
http://RoomForAll.blogspot.com http://AspartameNM.blogspot.com
http://health.groups.yahoo.com/group/aspartame/ 931 members, 18,831 posts
Aspartame Victims Support Group Edward Bryant Holman, Chief Moderator
http://www.presidiotex.com/aspartame/ bryanth@presidiotex.net
http://www.wnho.net/links-aspartame.htm many fine aspartame sites
http://groups.yahoo.com/group/aspartameNM/message/1223
complete info on NM EIB aspartame ban meeting, Oct. 4, Santa Fe,
Leland Lehrman, www.MotherMedia.org: Murray 2005.09.30
http://groups.yahoo.com/group/aspartameNM/message/1217
battle to ban aspartame heats up in New Mexico Environmental Improvement
Board, 9 AM Tuesday, October 4: Fox: Murray 2005.09.23
http://groups.yahoo.com/group/aspartameNM/message/1220
legal and factual basis for NM EIB to ban aspartame (methanol,
formaldehyde), final paragraph from James S. Turner, Esq, letters from
Kenneth P. Stoller MD (Pediatrics), C. Grant La Farge, MD (Pediatric
Cardiology), Karen Ulehla, MSLS, Medical Librarian: Murray 2005.09.27
http://groups.yahoo.com/group/aspartameNM/message/1218
James S. Turner, Esq. letter on improper approval of aspartame by FDA in
1981, to New Mexico Environmental Improvement Board 2005.09.20,
plain text: Murray 2005.09.24
http://groups.yahoo.com/group/aspartameNM/message/1215
Edward M. Johnson, J.D. Attorney, Texas, supports legality and necessity of
Fox petition for New Mexico Environmental Improvement Board
to ban aspartame: Fox: Murray 2005.09.15
http://groups.yahoo.com/group/aspartameNM/message/1225
Aspartame — the shocking story, Pat Thomas, The Ecologist, 2005 Sept.,
p. 35-51, full text: Murray 2005.09.30
http://groups.yahoo.com/group/aspartameNM/message/1106
hangover research relevant to toxicity of 11% methanol in aspartame
(formaldehyde, formic acid): Calder I (full text): Jones AW: Murray
2004.08.05 2005.09.28
Since no adaquate data has ever been published on the exact disposition of
toxic metabolites in specific tissues in humans of the 11% methanol
component of aspartame, the many studies on morning-after hangover from the
methanol impurity in alcohol drinks are the main available resource to date.
Jones AW (1987) found next-morning hangover from red wine with
100 to 150 mg methanol
(9.5% w/v ethanol, 100 mg/l methanol, 0.01%, one part in ten thousand).
Fully 11% of aspartame is methanol — 1,120 mg aspartame in 2 L diet soda,
almost six 12-oz cans, gives 123 mg methanol (wood alcohol) — the same
amount that produces hangover from red wine.
http://groups.yahoo.com/group/aspartameNM/message/1186
aspartame induces lymphomas and leukaemias in rats, full plain text,
M Soffritti, F Belpoggi, DD Esposti, L Lambertini: Ramazzini Foundation
study 2005.07.14: main results agree with their previous methanol and
formaldehyde studies: Murray 2005.09.27
http://groups.yahoo.com/group/aspartameNM/message/1189
Michael F Jacobson of CSPI now and in 1985 re aspartame toxicity, letter to
FDA Commissioner Lester Crawford; California OEHHA aspartame critique
2004.03.12; Center for Consumer Freedom denounces CSPI: Murray 2005.07.27
http://groups.yahoo.com/group/aspartameNM/message/1226
USA NIH National Toxicology Program aids eminent Ramazzini Foundation,
Bologna, Italy, in more results on cancers in rats from lifetime low
levels of aspartame (methanol, formaldehyde), Felicity Lawrence,
www.guardian.co.uk: Murray 2005.09.30
http://groups.yahoo.com/group/aspartameNM/message/1143
methanol (formaldehyde, formic acid) disposition: Bouchard M et al, full
plain text, 2001: substantial sources are degradation of fruit pectins,
liquors, aspartame, smoke: Murray 2005.04.02 rmforall
http://groups.yahoo.com/group/aspartameNM/message/1213
aspartame (methanol, phenylalanine, aspartic acid) effects, detailed expert
studies in 2005 Aug and 1998 July, Tsakiris S, Schulpis KH, Karikas GA,
Kokotos G, Reclos RJ, et al, Aghia Sophia Children’s Hospital, Athens,
Greece: Murray 2005.09.09
http://groups.yahoo.com/group/aspartameNM/message/1045
http://www.holisticmed.com/aspartame/scf2002-response.htm
Mark Gold exhaustively critiques European Commission Scientific
Committee on Food re aspartame ( 2002.12.04 ): 59 pages, 230 references
http://www.HolisticMed.com/aspartame mgold@holisticmed.com
Aspartame Toxicity Information Center Mark D. Gold
12 East Side Drive #2-18 Concord, NH 03301 603-225-2100
http://www.holisticmed.com/aspartame/abuse/methanol.html
“Scientific Abuse in Aspartame Research”
Gold points out that industry methanol assays were too insensitive to
properly measure blood methanol levels. ]
Fully 11% of aspartame is methanol– 1,120 mg aspartame in 2 L diet soda,
almost six 12-oz cans, gives 123 mg methanol (wood alcohol). If 30% of
the methanol is turned into formaldehyde, the amount of formaldehyde is 18
times the USA EPA limit for daily formaldehyde in drinking water, 2 mg in 2
L water.
http://groups.yahoo.com/group/aspartameNM/message/835
ATSDR: EPA limit 1 ppm formaldehyde in drinking water July 1999:
Murray 2002.05.30 rmforall
Aspartame is made of phenylalanine (50% by weight) and aspartic acid (39%),
both ordinary amino acids, bound loosely together by methanol (wood alcohol,
11%). The readily released methanol from aspartame is within hours turned
by the liver into formaldehyde and then formic acid, both potent, cumulative
toxins.
http://groups.yahoo.com/group/aspartameNM/message/1182
Joining together: short review: research on aspartame (methanol,
formaldehyde, formic acid) toxicity: Murray 2005.07.08 rmforall
http://groups.yahoo.com/group/aspartameNM/message/1071
research on aspartame (methanol, formaldehyde, formic acid) toxicity: Murray
2004.04.29 rmforall
http://groups.yahoo.com/group/aspartameNM/message/935
Comet assay finds DNA damage from sucralose, cyclamate, saccharin in
mice: Sasaki YF & Tsuda S Aug 2002: Murray 2003.01.01
[ Also borderline evidence, in this pilot study of 39 food additives,
using test groups of 4 mice, for DNA damage from for stomach, colon,
liver, bladder, and lung 3 hr after oral dose of 2000 mg/kg aspartame–
a very high dose. ]
http://groups.yahoo.com/group/aspartameNM/message/1131
genotoxicity of aspartame in human lymphocytes 2004.07.29 full plain text,
Rencuzogullari E et al, Cukurova University, Adana, Turkey 2004 Aug: Murray
2004.11.06 rmforall
http://groups.yahoo.com/group/aspartameNM/message/1088
Murray, full plain text & critique: chronic aspartame in rats affects
memory, brain cholinergic receptors, and brain chemistry, Christian B,
McConnaughey M et al, 2004 May: 2004.06.05 rmforall
http://groups.yahoo.com/group/aspartameNM/message/1067
eyelid contact dermatitis by formaldehyde from aspartame, AM Hill & DV
Belsito, Nov 2003: Murray 2004.03.30 rmforall
Thrasher (2001): “The major difference is that the Japanese demonstrated
the incorporation of FA and its metabolites into the placenta and fetus.
The quantity of radioactivity remaining in maternal and fetal tissues
at 48 hours was 26.9% of the administered dose.” [ Ref. 14-16 ]
Arch Environ Health 2001 Jul-Aug; 56(4): 300-11.
Embryo toxicity and teratogenicity of formaldehyde. [100 references]
Thrasher JD, Kilburn KH. toxicology@drthrasher.org
Sam-1 Trust, Alto, New Mexico, USA.
http://www.drthrasher.org/formaldehyde_embryo_toxicity.html full text
http://groups.yahoo.com/group/aspartameNM/message/939
aspartame (aspartic acid, phenylalanine) binding to DNA:
Karikas July 1998: Murray 2003.01.05 rmforall
Karikas GA, Schulpis KH, Reclos GJ, Kokotos G
Measurement of molecular interaction of aspartame and
its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7.
Dept. of Chemistry, University of Athens, Greece
http://www.chem.uoa.gr gkokotos@atlas.uoa.gr
K.H. Schulpis inchildh@otenet.gr G.J. Reclos reklos@otenet.gr
http://groups.yahoo.com/group/aspartameNM/message/1052
DMDC: Dimethyl dicarbonate 200mg/L in drinks adds methanol 98 mg/L
[ becomes formaldehyde in body ]: EU Scientific Committee on Foods
2001.07.12: Murray 2004.01.22 rmforall
http://groups.yahoo.com/group/aspartameNM/message/925
aspartame puts formaldehyde adducts into tissues, Part 1/2
full text Trocho & Alemany 1998.06.26: Murray 2002.12.22
http://groups.yahoo.com/group/aspartameNM/message/1065
politicians and celebrities hooked on diet sodas (aspartame):
Murray 2004.03.24 rmforall
http://www.dorway.com/upipart1.txt
http://groups.yahoo.com/group/aspartameNM/message/262
aspartame expose 96K Oct 1987 Part 1/3: Gregory Gordon, UPI reporter:
Murray 2000.07.10 rmforall
http://www.dorway.com/enclosur.html
http://groups.yahoo.com/group/aspartameNM/message/53
aspartame history Part 1/4 1964-1976: Gold: Murray 1999.11.06 rmforall
http://groups.yahoo.com/group/aspartameNM/message/928
revolving door, Monsanto, FDA, EPA: NGIN: Murray 2002.12.23 rmforall
http://groups.yahoo.com/group/aspartameNM/message/841
RTM: Merisant Co., MSD Capital, Dell Computer Corp., NutraSweet Co.,
JW Childs Assc.: aspartame-neotame toxicity 2002.07.10 rmforall
http://groups.yahoo.com/group/aspartameNM/message/857
www.dorway.com: original documents and long reviews of
flaws in aspartame toxicity research: Murray
2002.07.31 rmforall
http://groups.yahoo.com/group/aspartameNM/message/858
Samuels: Strong: Roberts: Gold: flaws in double-blind
studies re aspartame and MSG toxicity: Murray
2002.08.01 rmforall
“Survey of aspartame studies: correlation of outcome
and funding sources,” 1998, unpublished: http://www.dorway.com/peerrev.html
Prof. Ralph G. Walton, MD
http://www.truthinlabeling.org/ Truth in Labeling Campaign [MSG]
Adrienne Samuels, PhD The toxicity/safety of processed
free glutamic acid (MSG): a study in suppression of information.
Accountability in Research 1999; 6: 259-310. 52-page review
P.O. Box 2532 Darien, Illinois 60561
858-481-9333 adandjack@aol.com
http://groups.yahoo.com/group/aspartameNM/message/1224
Aspartame disease: an FDA-approved epidemic, H. J. Roberts, MD 2004:
Murray 2005.09.30
http://www.dorway.com/tldaddic.html 5-page review
Roberts HJ Aspartame (NutraSweet) addiction.
Townsend Letter 2000 Jan; HJRobertsMD@aol.com
http://www.sunsentpress.com/ sunsentpress@aol.com
Sunshine Sentinel Press P.O.Box 17799 West Palm Beach, FL 33416
800-814-9800 561-588-7628 561-547-8008 fax
http://groups.yahoo.com/group/aspartameNM/message/669
1038-page medical text “Aspartame Disease: An Ignored Epidemic”
published May 30 2001 $ 60.00 postpaid data from 1200 cases
available at http://www.amazon.com
over 600 references from standard medical research
http://groups.yahoo.com/group/aspartameNM/message/790
Moseley: review Roberts “Aspartame Disease: An Ignored Epidemic”:
Murray 2002.02.07 rmforall
Roberts, Hyman J., 1924- ,
Useful insights for diagnosis, treatment and public heath: an updated
anthology of original research, 2002, 798 pages,
aspartame disease, pages 627-685, 778-780
http://groups.yahoo.com/group/aspartameNM/message/859
Roberts: the life work of a brilliant clinician: aspartame toxicity:
Murray 2002.08.02 rmforall
A very detailed, highly credible account of the dubious approval process for
aspartame in July, 1981 is part of the just released two-hour documentary
“Sweet Misery, A Poisoned World: An Industry Case Study of a Food Supply
In Crisis” by Cori Brackett: cori@soundandfuryproductions.com
http://www.soundandfuryproductions.com/ 520-624-9710
2301 East Broadway, Suite 111 Tucson, AZ 85719
http://www.aspartamesafety.com marystod@airmail.net
Mary Nash Stoddard, Founder
Aspartame Consumer Safety Network and Pilot Hotline [1987-2004]
P.O. Box 2001 Frisco, TX 75034 1-214-387-4001 [ 25 miles N of Dallas ]
http://www.sweetpoison.com/ Janet Starr Hull, PhD, CN jshull@sweetpoison.com
Russell L. Blaylock, MD 601-982-1175 Madison, Mississippi
“Excitotoxins: The Taste that Kills”, 1977, 298 p., 493 references.
“Health and Nutrition Secrets that can save your life”, 2002, 459 p.,
558 + 30 references, $ 30 http://www.russellblaylockmd.com/
http://groups.yahoo.com/group/aspartameNM/message/1090
aspartame, MSG, excitotoxins, NMDA glutamate receptors, multiple sclerosis:
Blaylock: Martini: Murray 2004.06.25 rmforall
http://groups.yahoo.com/group/aspartameNM/message/97
Lancet website aspartame letter 1999.07.29:
Excitotoxins 1999 Part 1/3 Blaylock: Murray 2000.01.14 rmforall
The Medical Sentinel Journal 1999 Fall; (95 references)
http://www.dorway.com/blayenn.html
http://groups.yahoo.com/group/aspartameNM/message/1113
The Truth behind the Vaccine Coverup, Russell Blaylock MD:
Murray 2004.09.11 rmforall
[ My References [ not in PubMed ]
Blaylock RL.
Interaction of cytokines, excitotoxins, and reactive nitrogen and oxygen
species in autism spectrum disorders. J. Amer Nutr Assoc. 2003; 6: 21-35.
Blaylock RL.
The central role of excitotoxicity in autism spectrum disorders.
J Amer Nutra Assoc. 2003; 6: 7-19.
Blaylock RL.
Chronic microglial activation and excitotoxicity secondary to excessive
immune stimulation: possible factors in Gulf War Syndrome and autism.
J Amer Phys Surg. 2004; 9: 46-51. ]
George R Schwartz MD 7518 Old Santa Fe Trail Santa Fe, NM 87505
992-1455 drgschwartz@yahoogroups.com
www.healingresearch.org 424-9467 610-8143 cell
“In Bad Taste: The MSG Syndrome”, 1988, 123 p.
Eliza H Schmid MD (retired, now an artist)
http://www.dsg-art.com/s/schmid/ESBio1.html
http://www.democracyfornewmexico.com/democracy_for_new_mexico/2005/02/sf_air_america_.html
C. Grant La Farge MD Santa Fe Pediatric Cardiology
638B Harkle Road, Santa Fe 87505 505-982-7661 grantlaf@cybermesa.com
Raymond M. Singer, PhD, PA consulting toxicologist
36 Alondra Road / Santa Fe, New Mexico /87505
180 E. 79th Street Suite 1-C New York, N.Y. 10021
(505) 466-1100 Fax: (505) 466-1101 RaySinger@aol.com
http://members.aol.com/neurosite/
http://members.aol.com/DonationDrive/SingerPesticideNeuro.html
Singer, R. (1999, expected).
Neuropsychological evaluation of bystander exposure to pesticides.
The Journal of Neuropsychiatry and Clinical Neurosciences, 9, 1.
Deborah Werenko, MD 2801 Rodeo Road Suite B-13 Santa Fe 474-0120
Leah Morton, MD ABFP 505-983-8387
Bruce Gollub, MD ABFP
Isis Medicine 401 Botulph Lane Santa Fe, NM 87505
Erica M. Elliott, MD 505-471-8531 EricaMElliott@aol.com
#A-2 2300 West Alemada Santa Fe, NM 87501
family and environmental medicine
Prescriptions for a Healthy House, by Paula Baker, AIA, Erica Elliott, M.D.,
and John Banta (InWord Press, 1998, $29.95). Available from the Healthy
Housing Coalition. [ revised and updated, 2001 www.econests.com ]
http://www.bakerlaporte.com/downloads/H147BA.pdf healthy houses
Ann McCampbell, MD 505-466-3622
Chair, MCS Task Force of New Mexico
P.O. Box 23079 Santa Fe, NM 87502
These last three female physicians, and lastly, Jacqueline Krohn, have all
struggled with their own Multiple Chemical Sensitivity (Environmental
Illness), perhaps caused by exposure to formaldehyde in medical school. The
majority of aspartame reactors are female.
Jacqueline Krohn, MD [aspartame mentioned in her 3 books]
Los Alamos Medical Center 505-662-9620
3917 West Road, Ste. 136 Los Alamos, NM 87544
http://www.lapho.com/physicians/krohn.asp [photo]
Dr. Krohn received an MD from Washington University in 1976 and an MPH in
Occupational Medicine from the Medical College of Wisconsin in 1994.
Dr. Krohn is the co-author of these books: The Whole Way to Allergy Relief
and Prevention, Natural Detoxification, and Finding the Right Treatment.
http://www.annals.org/cgi/content/full/120/3/249-e
LETTER Controversy Over Multiple Chemical Sensitivities.
Jacqueline Krohn, MD; Jill Ryan, BA; and Julie Jacobson, PhD, MS, RN.
Annals of Internal Medicine February 1994; 120 (3): 249-251.
http://groups.yahoo.com/group/aspartameNM/message/1070
critique of aspartame review, French Food Safety Agency AFSSA 2002.05.07
aspartamgb.pdf (18 pages, in English), Martin Hirsch:
Murray 2004.04.13
http://groups.yahoo.com/group/aspartameNM/message/957
safety of aspartame Part 1/2 12.4.2: EC HCPD-G SCF:
Murray 2003.01.12 rmforall EU Scientific Committee on Food, a whitewash
http://groups.yahoo.com/group/aspartameNM/message/1045
http://www.holisticmed.com/aspartame/scf2002-response.htm
Mark Gold exhaustively critiques European Commission Scientific
Committee on Food re aspartame ( 2002.12.04 ): 59 pages, 230 references
http://www.eatright.org/Nutritive(1).pdf
J Am Diet Assoc. 2004 Feb; 104(2): 255-75.
Position of the American Dietetic Association: use of nutritive and
nonnutritive sweeteners. American Dietetic Association.
http://groups.yahoo.com/group/aspartameNM/message/1068
critique of aspartame review by American Dietetic Association Feb 2004,
Valerie B. Duffy & Madeleine J. Sigman-Grant: Murray 2004.05.14 rmforall
http://groups.yahoo.com/group/aspartameNM/message/1108
faults in 1999 July EPA 468-page formaldehyde profile:
Elzbieta Skrzydlewska PhD, Assc. Prof., Medical U. of Bialystok, Poland,
abstracts — ethanol, methanol, formaldehyde, formic acid, acetaldehyde,
lipid peroxidation, green tea, aging: Murray 2004.08.08 2005.07.11
http://groups.yahoo.com/group/aspartameNM/message/1140
EPA Preliminary Remedial Goals, PRGs, 2003 Oct, air and tap water —
methanol, formaldehyde, formic acid — not mentioned is methanol from
aspartame, dark wines and liquors: Murray 2004.11.20 rmforall
http://groups.yahoo.com/group/aspartameNM/message/1141
Nurses Health Study can quickly reveal the extent of aspartame (methanol,
formaldehyde, formic acid) toxicity: Murray 2004.11.21 rmforall
[ Any scientist can get access to this data for free by submitting a proper
research proposal. No one has admitted mining the extensive data on diet
soda use and many symtoms for decades for about 100,000 nurses. ]
**************************************************************
www.aspartame.org
The Calorie Control Council, established in 1966, is an international
non-profit association representing the low-calorie and reduced-fat food and
beverage industry.
Today it represents 60 manufacturers and suppliers of low-calorie, low-fat
and light foods and beverages, including the manufacturers and suppliers of
more than a dozen different dietary sweeteners, fat replacers and other
low-calorie ingredients.
Calorie Control Council 5775 Peachtree-Dunwoody Rd. www.CalorieControl.org
Bldg. G, Ste. 500 Atlanta, GA 30342 (404) 252-3663 fax (404) 252-0774
ccc@KellenCompany.com Webmaster@caloriecontrol.org
http://www.caloriecontrol.org/aspartame.html
” Upon digestion, aspartame breaks down into three components (aspartic
acid, phenylalanine and a small amount of methanol), which are then absorbed
into the blood and used in normal body processes.
Neither aspartame nor its components accumulates in the body.
These components are used in the body in the same ways as when they are also
derived from common foods.
Further, the amounts of these components from aspartame are small compared
to the amounts from other food sources. For example, a serving of no-fat
milk provides about 6 times more phenylalanine and 13 times more aspartic
acid compared to an equivalent amount of diet beverage sweetened 100% with
aspartame. Likewise, a serving of tomato juice provides about 6 times more
methanol compared to an equivalent amount of diet beverage with aspartame. ”
http://www.kellencompany.com/lnabors.html
LYN O’BRIEN NABORS Vice President LNabors@kellencompany.com
Lyn O’Brien Nabors serves as Vice President, Research Services and Account
Executive for The Kellen Company.
She has more than 23 years of experience in the association management
industry and directs the activities of two client associations.
Lyn supervises the research function of The Kellen Company and is
responsible for the coordination of scientific programs for several client
associations.
She is involved in presenting comment on various food ingredients to
scientific and regulatory agencies and new low-calorie ingredient approvals
and coordinated activities resulting in the removal of the saccharin warning
label requirement.
She works closely with clients on industry labeling issues and is
responsible for the development and updating of the company’s food industry
labeling manual.
Lyn is editor of three editions of Alternative Sweeteners, a comprehensive
textbook providing fundamental scientific and technical information on a
broad range of sweeteners.
She also has authored a number of book chapters and numerous journal
articles on low-calorie foods and beverages, sweeteners and fat replacers.
Lyn is a Phi Beta Kappa graduate of the University of Kentucky with a degree
in Public Health.
Prior to joining The Kellen Company in 1980, Lyn worked for several years in
the scientific field performing both laboratory and clinical research.
She is a member of the Institute of Food Technologists, serving three years
as an IFT Scientific Lecturer, and the American Chemical Society.
She currently serves as Executive Vice President of the Calorie Control
Council and President of the International Food Additives Council.
World Rev Nutr Diet. 1999; 85: 140-5.
Consumer perceptions of products containing sweeteners: USA.
Nabors LO.
Calorie Control Council, Atlanta, Ga., USA. lnabors@assnhq.com
Publication Types: Review Review, Tutorial PMID: 10647346
***************************************************************
October 5th, 2005 at 8:05 pm
Thanks so much for posting that Rick. An unbelievable bulk of info there that’s going to take me an age to get though!
November 22nd, 2005 at 5:10 am
I love asparitime soooo much it makes me dizzy and sick.